Multisystem inflammatory syndrome in children (MIS‐C) is a rare, but serious complication associated with COVID-19. MIS-C is causes parts of the body can become inflamed. This could include inflammation of the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs or clotting disorders of the blood.

To support emergency providers, Wisconsin Emergency Medical Services for Children (WI EMSC) has developed two resources to assist emergency providers care for children with suspected MIS-C.

MIS-C Clinical Pathway

Audience: Emergency department, inpatient unit, and pediatric intensive care unit (PICU) providers

Purpose: To assist hospital-based healthcare providers in evaluating pediatric patients for MIS-C and quickly identify children that should be transferred to tertiary pediatric centers.


Audience: EMS providers

Purpose: To provide general background information on MIS-C, clinical signs of MIS-C and pre-hospital treatment for MIS-C.

For additional resources related to MIS-C, please visit the Center for Disease Control and Prevention (CDC) MIS-C webpage